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KMID : 0369820150450040385
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Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 4 p.385 ~ p.398
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Preformulation and physicochemical interaction study of furosemide with different solid lipids
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Ali Hasan
Sandeep Kumar Singh
Verma Priya Ranjan Prasad
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Abstract
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The aim of the present work was to prepare and characterize the matrices of Furosemide (FRSM) with different solid lipids (Compritol 888 ATO, Hydrokote C, Imwitor 491, Imwitor 372P, and Witepsol H12) using Fourier transform infrared (FTIR), Raman, differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy. The solubility of FRSM in various solid lipids followed the order of; Compritol 888 ATO > Witepsol H12 > Hydrokote C > Imwitor 491 > Imwitor 372. FTIR, Raman, DSC and XRD studies indicated no chemical interactions with Compritol 888 ATO, Imwitor 491 and Imwitor 372P. Scanning electron microscopic images of lipids, melted lipids, FRSM and FRSM-lipid matrices showed different morphological characteristics. In vitro drug release study showed the sustained release of drug from all lipid-matrices that followed Higuchi and Korsmeyer?Peppas model except FRSM-Hydrokote matrix. The best fit model of FRSM-Hydrokote matrix was zero order (R2 = 0.978). Conclusively, Compritol 888 ATO was selected as lipid of choice owing to maximum solubility, least chemical interaction and better sustained release profile.
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KEYWORD
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Physicochemical interaction, Lipids, PXRD, DSC, Raman, FTIR
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